Ernest Lee, MD, PhD

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis.

Lande R, Lee EY, Palazzo R, Marinari B, Pietraforte I, Santos GS, Mattenberger Y, Spadaro F, Stefanantoni K, Iannace N, Dufour AM, Falchi M, Bianco M, Botti E, Bianchi L, Alvarez M, Riccieri V, Truchetet ME, C L Wong G, Chizzolini C, Frasca L PMID: 31043596

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O PMID: 31043745

Ernest Lee, MD, PhD

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis.

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Off-label studies on apremilast in dermatology: a review.

Unifying structural signature of eukaryotic α-helical host defense peptides.

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9.

Machine learning antimicrobial peptide sequences: Some surprising variations on the theme of amphiphilic assembly.

Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors.

What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?

Multigenerational memory and adaptive adhesion in early bacterial biofilm communities.

Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors.